This is not to say that you should start smoking. Cigarettes have tars that are definitely bad, cancer causing. Still, perhaps one needn’t be as anti smoking or vaping as the public has gotten. It’s also a starting point for research.
It seems that there are two things in cigarettes that protect against Parkinson’s. The first appears to be nicotine. We know this because chewing tobacco is shown to be protective at a rate similar to smoking. Another protective component appears to be carbon monoxide. Here is a study showing that low concentration carbon monoxide protects against Parkinson’s. The Michael J foundation is funding further studies on CO because low level CO seems promising as a treatment. There are also drugs that release compounds similar to CO that might treat, or prevent Parkinson’s.
Reduced rates of smoking has been cited as an explanation for the increasing PD rates world-wide. Similar to coffee and smoking, there are also health benefits for small amounts of radiation, sunlight, and chocolate. What is a healthy food has never been settled science; the data is entirely contradictory. All this is to say, that wide bans on big sodas, smoked meats, chewing tobacco, or e-cigarettes probably are misguided. For all we know they may be good for public health, and certainly aren’t sot bad as to justify wide bansand condemnations.
In theory, both US parties are committed to a balanced budget. Both claim they’ll tax as much as they spend, and we’ll pay our debts. In practice, both parties overspend wildly, year after year. The growth in non-defense spending (pork) is particularly egregious, see graph. For fiscal 2024, the 12 month period ending Sept. 30 2024, the government spent $6.75 trillion ($6750 billion), over 20% of GDP and 37% more than the $4.92 trillion we took in in taxes ($4,920 Billion). The difference, $1830 billion, was added to the national debt, already at $34 trillion, pushing it to $36 trillion, that’s more than 100% of our GDP. The interest cost alone is $1.22 trillion per year, 1/4 of our tax income.
Trump campaigned claiming he was going to balance the budget, but he has not (yet). There were some attempts via DOGE, saving about $214 billion, but the DOGE boys were outed, attacked, and gave up. And now the Democrats have forced a shutdown, using their power to prevent additional borrowing. This leaves Trump with a choice, either balance the budget or accept their spending demands. The expectation is that Trump will fold: there is no way he can find $1830 billion/year. Otherwise, many of the governments 4.2 million workers will go without pay, and many important services will stop.
So far, three weeks in, Trump seems fairly successful at keeping most things running while trying to balance the budget. Even if he fails, as seems likely, we will benefit from the attempt, I think.
Some government services are guaranteed to continue despite the shutdown: Social security and the post office because they are funded separately. Similarly, the patent office, the ports, and the airports. In the past some had to shut, but Trump has raised fees so they remain open and operating.
Essential workers, 800,000 people including customs agents and air traffic controllers continue working with most going unpaid. Trump committed to paying active duty military and for the WIC food program using money raised by new, 2025 tariffs. Tariffs are currently bringing in ~$300 Billion/ year, and so far tariffs mostly don’t affect ordinary folks, and help return manufacturing to the US. Some time soon we’ll have to pay the necessary workers and also some 750,000 non-necessary employees including: half the Dept. of Education, most of NASA and Energy.. They are not really useless, but are doing nothing essential to the day-to-day operation of the country.
Trump seems committed to removing many non-necessary workers in an effort to streamline and balance the budget. He fired 4200, bought out another 25,000 earlier this year, and has issued pre-termination notices to 75,000. A federal judge has blocked all firings as unlawful, but my sense is they are quite lawful and mostly beneficial. If you can’t fire non-working, un-necessary workers that you can’t afford to pay, who can you fire?
I suspect the shutdown will last well into November, well past the election, and that more folks will be fired or bought out. The key November crossroads will be food stamps, SNAP. These benefits are scheduled to end November 1 baring an end to the shutdown. Normally the bill is $110 billion/year, but Trump has eliminated benefits for illegal aliens and asylum seekers, and has instituted tougher work requirements. Democrats seem certain that Trump will fold. For the 11th time they scotched a bill to fund this and reopen the government and pay SNAP. I suspect that, at the last minute, Trump will find savings, or left-over funds and will keep SNAP funded through November.
Among the new savings, Trump ended the EV subsidy last month, saving about $7.5 billion/year ($7500 x 1 million EVs), and has negotiated some reductions in drug costs. He also increased the tariff on some Chinese and Canadian goods appropriate for rectifying trade imbalance, it’s been blocked by a federal judge. He’s also cancelled some rail work and research, saving $28 billion, and cancelled $20 billion for hydrogen hubs, and 83% of USAID. Also two navy ships that were years behind schedule and billions over budget. We need the ships, but don’t have the money. So far, this saved enough to pay all military servicemen.
Beyond this, I hope he cuts Biden’s high speed rail plans: $550 Billion for fast trains, Chicago to Seattle, Detroit to Toledo, San Francisco to LA, etc. The investment is $1,500 per person in the US. The eager thinkers overseeing this would never invest their own money, but are happy to invest everyone else’s. I also hope to see the end of NASA’s SLS rocket to the moon, nice but far more expensive than Falcon. We could also cancel some F35s ($0.1 Billion each to buy, and far more to maintain). Musk suggested replacing them with drones. I don’t know that these savings are enough. I don’t know how long we can continue, but each day shut, we move closer to a balanced budget, and that’s a good thing.
Robert Kennedy Jr. recently started the process to add a warning to the labels of acetaminophen products, including Tylenol, noting a correlation between its use during pregnancy and autism and ADHD in children. The advisability of this is controversial. Experts at Scientific American say “the evidence against Tylenol is thin,” The British Journal, Nature, went further: “It’s Dangerous to Avoid Tylenol While Pregnant”, reversing its call for caution. Similarly, Barak Obama: “Trump’s announcement is violence against the truth.” Nature’s current logic is that any risk of Autism and ADHD is smaller than the risk if pregnant women do not take fever medication. Given the confusion and politicalization of the topic, I thought I’d write about the magnitude of the risk, and the logic to think Tylenol causes autism and ADHD.
The evidence that there is some, large risk agent is the tremendous rise in the prevalence of autism and ADHD over the last 50 years, see chart above. The rise t matches the rise in the use of Tylenol as opposed to older medications, like aspirin. Correcting for other changes (confounders), this Oxford study finds 95% certainty association of acetaminophen with ADHD; care being taken to remove confounders.
In terms of the magnitude of the Tylenol effect, this study from Johns Hopkins, compared fetal blood levels of acetaminophen enzymes (measured in the umbilical cord) to the risk of autism and ADHD. As shown below, there is roughly a three-times increase in risk for both in every sub-group of child: male and female, black and white, pre-term and full term, drug user or not, breast fed or not, fevered mother or not. Children with higher blood-acetaminophen levels (2nd, 3rd tercile) always have a higher chance of ADHD and ASD — about 3 times higher– than children in the lower tercile.
The higher cohorts of blood Tylenol is associated with higher risk of ASD and ADHD for every subgroup.
This European study found a similar association, but measured Tylenol use based on interviews. Between these studies, I find it reasonable to advise caution. This is the sort of evidence that caused us to put cancer warnings on cigarettes, caused us to caution against alcohol during pregnancy, and caused the mandate for seatbelts. This is usually what scientists use, it’s the best approach we have. I do not suggest dropping all fever medication, but suggest switching to older medications, like aspirin, or cool showers, or following the Harvard medical journal advice to take Tylenol in the minimum dose.
An upside to the political divide is that we’re likely to have better evidence in coming years. in Republican-leaning states, doctors have mostly favored the advisory. Meanwhile,in D-leaning states women are ignoring the advisory, some even filming themselves taking extra Tylenol, in distain for Trump. These two groups provide a controlled study, so that we should have have better data regarding Tylenol safety in 2-3 years.
Added Oct. 20,2025: A cynical counter argument to the above, suggested by me ten years ago and others, is that there is no spike in ADHD, that it’s a scam perpetrated by teachers who prefer drugged students to antsy ones. If so, one could argue that the same genetics that make students antsy (ADHD and semi autistic) also affect Tylenol metabolism and use: Parents of such children take more Tylenol. Here is a good Swedish study that supports this view. If this proves to be true, the real scandal is how many normal students, mostly boys, have been drugged up and mis-educated.
This post was inspired by articles like the one below asking how it was that some Americans, MAGAs think Trump is good when everyone of value sees him as a fat, bigoted, criminal clown. The Atlantic’s answer is they’re detached from classic ideals of good or moral, and are now fueled by “narcissism, fanaticism, and authoritarianism”. I thought a more helpful explanation was that we’re going through a paradigm shift, perhaps progressing in our thought of what it means to be good.
Consider Thomas Kuhn’s analysis of scientific progress. Tomas Kuhn was a major American Philosopher of the 1960s-70s who claimed that science progress was not uniform but included long periods of “normal science” punctuated by change. A “crisis” leading a “Revolution” resulting in big changes in language, outlook and thinking, a “paradigm shift”. In the midst of these scientific revolutions, the experts of the old system fight bitterly against the new while being confounded by the fact that it seems to work.
Consider the resistance to relativity and quantum mechanics. Before 1905 the experts were doing fine: Professors taught and students learned — formulas, tools and techniques were handed over. Educated had respect and money, and could communicate. There were some few contradictions, as in why the sun burned hot, or why the sky was blue, but one could ignore these. You knew who the experts were, and they didn’t include Einstein, Bohr, Pauli, Plank.
Democrats sell red hats and buttons with Fascist or Felon because Trump’s red MAGA (Make America Great Again) hats work for him.
But then came a few more problems, (inconsistencies in Kuhn-speak: radioactivity, photoelectrons, the speed of light… Einstein published on them in 1905, thoughts that few took seriously: imaginary time was a fourth dimension at right angles to the others, etc. The explantations seemed mad and for 14 years after he published, Einstein could not get a university job — anywhere. By 1919 detailed experiments suggested he might be right on a lot of things. It lead to the rise of a new group of experts plus a loss of esteem for the old, and a bunch of crank explainers who were neither but flourished in the confusion.
Hate abounded; new weapons and cures WWI removed aristocrats and beards. A popular book a lecture series of the time was “100 scientists against Einstein.” There followed a lost generation with no clear foundation. It took 50 years to resolve confusion, but there developed new thought leaders, a new language, new standard formulas and books were sold, and we were returned slowly to “normal science” in a new thought paradigm.
I see the conflict of opinion surrounding Mr Trump as a crisis in political thought similar to the crisis in science thought 100 years ago. Polite discourse if gone, replaced by stunts and insults. The government is currently shut, with 40% federal workers, those whose jobs are non-critical, on unpaid leave. It’s a collapse, not of morals, but of language. Trump hopes to use the shutdown, I think, to show that most of these 40%, are not needed. If they are not needed, it reflects a big lack in government — actually a big bloat in government. You can see why the opponents of cuts see Trump as a fascist who uses “dog whistles” to motivate “his base”, there is a lack of communication and a fear Trump may be right too, I think. The experiment in smaller government is being run as I write, and Trump seems confident that some 400,000 federal workers are not needed. Are they? Instead of debating, we’ve got to violence: two attempts on Trump’s life so far, the main college debater, Charlie Kirk, shot dead. Appropriate, I think, is Bob Dylan’s, “Times are a-changing” and “something is happening here, but you don’t know what it is, do you, Mr Jones.”
Other questions are being worked out as we speak -sending chills through the old order: Are China and Europe “ripping us off,” by free trade and stolen technology? Are tariffs an answer. Canadian and European leaders deride these thoughts openly, but I notice that both Canada and the EU have put heavy tariffs on Chinese goods.
Another issue is respect for experts. The Atlantic bemoaned that Trump supporters don’t respect experts on health, climate, and education, but perhaps they are lying. The seas have not risen as expected. Some warming may be good, or better than the remedies. Even if RFK Jr.’s ideas are wrong it seems that science has become unreliable (irreproducible), and that elite colleges aren’t fair in their assessment, nor do they provide great value.
Eventually things will settle down; we will some day have polite discourse. In 40-50 years, I suspect we’ll agree that some tariffs are good and that Trump’s tariffs are either to high or low, We’ll think that the climate push to no nuclear power, was a mistake, as was the giant, Ivanpah solar farm). And we’ll be able to discuss it civilly. I hope the change in thought takes less than 50 years.
Robert Buxbaum, October 3, 2025 – we are now entering another physics crisis too, I think.
